Detalhe da pesquisa
1.
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Nature
; 537(7619): 229-233, 2016 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27501246
2.
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33753338
3.
Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington.
Clin Infect Dis
; 71(16): 2167-2173, 2020 11 19.
Artigo
Inglês
| MEDLINE | ID: mdl-32444880
4.
Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.
J Antimicrob Chemother
; 75(5): 1218-1227, 2020 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32011682
5.
A new chemotype with promise against Trypanosoma cruzi.
Bioorg Med Chem Lett
; 30(1): 126778, 2020 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31706668
6.
A 71-year-old man with recurrent pulmonary mycobacterial avium complex infections and lymphopenia.
Allergy Asthma Proc
; 41(1): 66-69, 2020 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31888785
7.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30745384
8.
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28848016
9.
Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Bioorg Med Chem Lett
; 27(12): 2702-2707, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28465105
10.
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Bioorg Med Chem
; 25(5): 1571-1584, 2017 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28187957
11.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 8): 1684-98, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-26249349
12.
Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.
Antimicrob Agents Chemother
; 59(11): 7128-31, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26324270
13.
Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.
Antimicrob Agents Chemother
; 57(7): 3021-8, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23587950
14.
Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents.
Bioorg Med Chem Lett
; 23(23): 6492-9, 2013 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24120539
15.
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 9): 1194-200, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22948920
16.
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Antimicrob Agents Chemother
; 56(9): 4914-21, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22777048
17.
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.
Antimicrob Agents Chemother
; 55(5): 1982-9, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21282428
18.
Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.
Chem Rev
; 114(22): 11305-47, 2014 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25365529
19.
Screening a fragment cocktail library using ultrafiltration.
Anal Bioanal Chem
; 401(5): 1585-91, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21750879
20.
Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads.
ACS Infect Dis
; 7(7): 1874-1876, 2021 07 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33871981